Everything about the lab industry

Pharmaceutical testing is a must to ensure that all medications meet the top quality, safety, and performance requirements before they enter the market. CD Formulation’s cGMP-compliant laboratory is well-equipped to identify both the chemical and structural composition of each drug substance. More recently, the company announced to broaden its service range to tablet fragility test, dissolution test, and disintegration test. “Staffed with a group of pharmaceutical experts specialized in chemistry, biochemistry, and engineering, CD Formulation has grown to be one of the finest contract service organizations. Our testing laboratories have both expertise and experience to handle the most complex formulation problems,” said the Marketing Chief of CD Formulation. “Our analysis and testing services will support pharmaceutical companies at every step and phase of the drug development lifecycle, making sure the entire drug development process complies with the latest regulatory standards and requirements.” Below are some of the testing services newly introduced by CD Formulation: Tablet Fragility Test The tablet fragility test is purposed to determine the resistance of tablets against mechanical stress, both shaking and erosion. Theoretically speaking, the higher the percentage of fragility, the greater the loss of tablet life. The physical and chemical properties and stability of API have a great influence on the friability of tablets. Other factors such as excipients and the production process will influence tablet fragility as well. CD Formulation’s experienced analysis experts can perform tablet fragility tests by pharmacopeia methods, helping clients to conduct an appropriate risk assessment of the finished drug. Dissolution Test Drug dissolution test is a standardized method for measuring the release rate of a drug from a given dosage form, which helps to evaluate the performance of a drug. CD Formulation’s dissolution testing is performed under specified conditions according to specific applicable pharmacopoeial standards, such as Four Dissolution Apparatuses Standardized, USP Dissolution Apparatus 1 – Basket (37 °C ± 0.5 °C), USP Dissolution Apparatus 2 – Paddle (37 °C ± 0.5 °C), USP Dissolution Apparatus 3 – Reciprocating Cylinder (37 °C ± 0.5 °C), and USP Dissolution Apparatus 4 – Flow-Through Cell (37 °C ± 0.5 °C). Disintegration Test The disintegration test is to evaluate the ability of a sample, mostly tablets, capsules, and enteric-coated tablets, to break into smaller particles under standard conditions. The results will provide critical safety data on the bioavailability of drugs in vivo without the use of in vivo methods. At CD Formulation, a series of methods such as the test-tube method, sieve method with shaker, sieve method, and pharmacopoeial method are used to test disintegration for drugs. Please visit the website to learn more. About Successfully solving drug formulation and delivery issues for its global customers is always the goal of CD Formulation. Equipped with advanced facilities that comply with GMP regulations, CD Formulation is of great help to pharmaceutical companies during the progress of formulation, from initial pre-formulation trials to commercial manufacturing. Moreover, after years of untiring efforts, the company has also extended its product lines to pharmaceutical excipients, cosmetic ingredients, food ingredients, offering almost 1,000 excipients or raw materials across the globe.

Lifeasible, a plant biotechnology company that offers efficient and reliable seed testing services with expanding capacities, now provides seed vigor testing service to meet the diverse requirements of its customers. Seed vigor is the sum of all essential properties that determine the potential for rapid, uniform germination as well as the ability to develop into normal seedlings under a wide range of growth conditions. The goal of seed vigor testing is to evaluate the seed's performance under adverse conditions. It is regarded as the most reliable method for accurately predicting potential field performance. With extensive experience and expertise in modern agriculture, Lifeasible is proud to provide cutting-edge technologies, advanced laboratory facilities, and high-capacity field stations to its customers worldwide. Seed vigor testing services at Lifeasible mainly include: Accelerated aging test, Controlled deterioration test, Conductivity test, Cold test, Saturated cold test, Tetrazolium (TZ) vigor test, Cool germination test, Growth test, Hiltner test (Brick grit test), Paper piercing test, and Osmotic stress test. Lifeasible's seed laboratory is dedicated to providing high-quality seed vigor testing services. Because of it specialized experts, fully-fledged technologies, and large capacity laboratories, the company can perform high-throughput sample testing with superior efficiency and reliability. In addition, Lifeasible offers seed testing of moisture content, germination, tetrazolium, vigor, and health. One-stop service for seeding testing covering all steps including sampling, testing, surveys, verification, and monitoring is available at Lifeasible. A wide range of crops (agriculture crops, grasses, native species, forbs, vegetables, flowers, herbs, and shrubs) are covered by the seed testing service by Lifeasible through high-quality standards. “Whatever challenges you may face during plant science research, we are always ready to provide unique solutions to meet your needs.” Said Isla, one of the representative speakers from Lifeasible. To know more detailed information about the seed vigor testing service supplied by Lifeasible, please visit our website.

Profacgen, a biotechnology company that offers a broad service portfolio designed to provide versatile and reliable platforms for protein production and research, recently released protein-carbohydrate docking for its molecular docking service, offering unparalleled opportunities for drug discovery. Carbohydrates participate in numerous important signaling pathways, and carbohydrate recognition is an essential component of many biological processes such as innate immunity, metabolism, and immune response. Glycans on cell surfaces, for example, or secreted biomolecules, play an important role in cell-cell interactions, including interactions between host cells and pathogens. Glycan-protein interactions are gaining importance in the field of structure-based drug design due to their physiological and pathological significance. However, because sugar moieties typically have a heterogeneous chemical structure and conformation, studying these interactions using X-ray crystallography has been notoriously difficult. Computational molecular modeling techniques provide an appealing alternative method for investigating protein-carbohydrate recognition and specificity. At Profacgen, scientists predict these protein–carbohydrate interactions through the combination of a genetic conformational search algorithm coupled with an empirical free energy function specific for carbohydrates. Its docking procedure allows for a systematic exploration of carbohydrate ligand orientations and positions within a protein cavity (which is typically more open and less well-defined than small molecule binding sites) and assesses free energies of complex formation. Experiment-derived constraints can also be applied to the docking protocol to restrict the search space for the sugar as well as the protein molecule. The energy function is specifically designed for carbohydrates, which is used for the clustering of binding poses and exploration of the most energetically favorable complex structure. “Our computational modeling method is well suited to provide an atomic-level understanding of carbohydrate recognition which reveals some of the distinctive molecular features unique to protein-carbohydrate complexes. We can also help to predict the interaction between proteins and single carbohydrate ligands and the binding poses and binding affinities of glycans to glycan-binding proteins.” Said Crystal, the chief marketing staff at Profacgen. Visit our website to know more about the protein glycan docking service provided by Profacgen.

Matexcel, a biotechnology company in material science, recently updated its Photovoltaic Product Analysis Service to assist scientists and researchers better with their projects. Products that use solar cells to transform light energy into electrical energy are referred to as photovoltaic products. In a broad sense, photovoltaic products refer to items like solar street lights, traffic lights, sign lights, navigational markers, etc. that use the current produced by the photovoltaic effect as energy. Photovoltaic products, in a strict sense, refer to photovoltaic power generation systems, components, and photovoltaic cell components. Solar cells are not the only photovoltaic products available today. The more popular photovoltaic products, for instance, include solar power generation system equipment, photovoltaic power supplies and batteries, photovoltaic seawater desalination systems, photovoltaic power generation system computer application software, and photovoltaic curtain wall glass. They are all environmentally friendly and energy-efficient products. At present, Matexcel effectively supports independent R&D advancement through qualitative and quantitative analysis of complex structures by NMR, IR, GC-MS, etc. With the help of photovoltaic raw material analysis, it is possible to effectively manage the quality of raw materials and lower the rate of product failure that rises as a result of variations in material properties. Testing services at Matexcel mainly include: Chemical composition analysis/ Mechanical strength test/ Thermal analysis test of photovoltaic materials and auxiliary materials. Photovoltaic Module Analysis Crystalline silicon photovoltaic module testing, Planar photovoltaic module testing, Ground photovoltaic module testing, Photovoltaic module testing, Crystalline silicon photovoltaic module testing, etc. Photovoltaic Product Non-Destructive Analysis Ultrasonic Testing (UT), Radiography (RT), Magnetic Particle Testing (MT), Penetration Testing (PT), Ultrasonic Phased Array (PA). Photovoltaic Raw Material Analysis Testing products include: EVA, backplane, laminate, reflective film, junction box, silica gel, POE, glass, cell, wafer, silicon material, slurry, etc. Please visit our website to know more about the updated photovoltaic product analysis service provided by Matexcel.

Earlier this month, the management of CD Formulation announced the launch of active ingredients, antioxidants, and chelating chemicals for customers worldwide who are involved with cosmetic manufacturing and processing. These three types of chemicals are now available for use in the cosmetic industry as raw materials. The cosmetics market has expanded dramatically over the past few decades. Among all varieties, natural and organic facial cosmetic products are preferred by the majority of consumers. Thereby, the manufacturers are now focusing on innovating facial cosmetics with natural ingredients. “As a well-established supplier of excipients, we put quality and safety in the first place. We provide a full range of cosmetic ingredients, either its high-performance actives or unique functional ingredients, natural fragrances or some other sustainable alternatives,” said the Marketing Chief of CD Formulation. Below are the offerings launched this month by CD Formulation: Active Ingredients Active ingredients in cosmetics refer to the efficacious ingredients of maintenance products and will be found in products such as sunscreen, whitening, anti-acne, or products claiming efficacy. Because active ingredients are considered to have drug allergy effects, the amount and specific effects of each active ingredient must comply with the regulations of the competent authorities. Active ingredients can be roughly classified into anti-acne ingredients, anti-dandruff ingredients, anticaries ingredients, antiperspirant ingredients, astringents, lip protectants, skin protectant ingredients, skin protectants, and sunscreens. Some of the active ingredients supplied by CD Formulation are: Turmeric, Charcoal, Retinol, Lavender, Resveratrol, Inosine, Formononetin, Rosemary Herb Extract, Aluminum Chlorohydrate, Titanium(IV) oxide, Sodium fluoride, Sodium fluorophosphate, Tin(II) fluoride, etc. Antioxidant Cosmetic Chemicals Antioxidants are important in any product that contains oils or other ingredients that are susceptible to oxidation. The use of antioxidants in balms, salves, lotions, and creams can increase the stability of the oil in the product, thereby extending the shelf life of the product. BHA, BHT (butylhydroxytoluene), TBHQ (tert-butylhydroquinone), and tocopherol are the most commonly used antioxidants. At CD Formulation, customers can easily find the following antioxidants: 4-Methoxyphenol (CAS 150-76-5), Alpha Tocopherol (CAS 10191-41-0), Arbutin (CAS 497-76-7), L-Ascorbic acid (CAS 50-81-7), Ascorbyl Palmitate (CAS 137-66-6), Asiaticoside (CAS 16830-15-2), Butylated hydroxytoluene (CAS 128-37-0), Caffeic Acid (CAS 331-39-5), Calcium L-ascorbate dihydrate (CAS 5743-28-2), Chlorogenic acid (CAS 327-97-9), L-Cysteine hydrochloride monohydrate (CAS 7048-04-6), (+)-α-Tocopherol acetate (CAS 58-95-7), Ellagic acid (CAS 476-66-4), Hydroxylamine hydrochloride (CAS 5470-11-1), L-Cysteine (CAS 52-90-4), and more. Cosmetic Chelating Chemicals Chelating agents can help extend the shelf life of cosmetic products and minimize environmental risks. When used in combination with antioxidants such as tocopherols, chelating agents help protect valuable ingredients such as unsaturated oils. Some of the chelating agents (https://www.formulationbio.com/products/cosmetic-chelating-chemicals.html) offered by CD Formulation are listed here: (1,2-Cyclohexylenedinitrilo)tetraacetic Acid, Reagent (CAS 125572-95-4), 2-Hydroxypropyl-β-cyclodextrin (CAS 128446-35-5), (2-Hydroxypropyl)-γ-cyclodextrin (CAS 128446-34-4), Ethylenediaminetetraacetic acid (CAS 60-00-4), 8-Quinolinol hemisulfate salt (CAS 134-31-6), 8-Hydroxyquinoline (CAS 148-24-3), Humic acid (CAS 1415-93-6), Phytic acid solution (CAS 83-86-3), Methyl-β-cyclodextrin (CAS 128446-36-6), Mucic acid (CAS 526-99-8), Potassium D-gluconate (CAS 299-27-4), Citric acid trisodium salt (CAS 68-04-2), etc. Please visit the website to explore more. About Known for its robust expertise and profound professionalism, CD Formulation not only serves as a trust-won CRO service provider for pharmaceutical companies to solve drug formulation-related challenges, but also works as a famed supplier of a full range of excipients, cosmetic ingredients, and food ingredients.