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Reduced workplace noise pollution image
Safety
Reduced workplace noise pollution
Alongside environmental pollution through harmful substances, people are increasingly exposed to a new hazard: Growing environmental pollution through sounds and, even worse, through noise. Constant stress caused by noise can make people ill. The detrimental effects on health resulting from noise are extremely varied. They range from serious damage to hearing to hidden symptoms that usually develop slowly over many years, such as sleeping disorders, irritability or nervousness. While it is possible to take measures to reduce or avoid noise in one’s private life, this is often not possible in the workplace. The employer is obliged to take measures to keep the sound pressure level as low as possible. The requirements in respect of the cleanliness of laboratory environments and commercial premises have increased dramatically, particularly in the areas of industrial production, packaging and in analytics and medical laboratories and research. A particulate-free, sterile environment is often crucial in such fields. Small, local clean-room workbenches or laminar flow boxes meet these demands and protect the work area from particles, germs and dust. The way in which a flow box works is quite simple. The ambient air is sucked in by a fan and forced through a HEPA H14 type particle filter. Many customers find the unavoidable fan noise disturbing over the long term. Spetec GmbH therefore made it a priority to develop a particularly low-noise fan concept in collaboration with a fan manufacturer. The placement of the filter creates a laminar air flow in the working area. The purified air generates overpressure and acts as a curtain to protect the sample from the ingress of particles. All Laminar Flow Boxes of the CleanBoy range remain below the noise level of a normal office (55 db) in normal operating mode. In this mode, the Spetec Laminar Flow Module FMS 37 has a noise level no greater than quiet music. Even at its highest performance level, the noise level does not exceed the values prescribed for industrial workplaces (80 db). In terms of noise emissions, Spetecs’ laminar flow boxes meet all the requirements for minimizing noise pollution in the workplace. The achievable noise level reflects the current state of the art in fan technology, and none of the module sizes offered exceeds the values prescribed for general-purpose offices during normal operation. They can be fitted (as ceiling-mounted versions) or installed as floor-standing versions in existing analytical laboratories, as well as in electronic and optical manufacturing facilities or in the packaging lines for medical or pharmaceutical products. And all this without costly building work or any modification to the existing air-conditioning systems.
'Supply of Clinical Standards for Chemistry Laboratory Use' image
Tech & Analysis
Supply of Clinical Standards for Chemistry Laboratory Use
Following varieties of certified reference materials such as environmental standards, food & beverage standards, forensic and veterinary standards, life sciences standards, petrochemical standards, and pharmaceutical and drug standards, earlier this month, Alfa Chemistry commenced the supply of clinical standards for customers worldwide to support clinical laboratory use. Chromatography is a laboratory technique to separate mixtures into single components. When conducting chromatography experiments, different analytical reagents are used depending on the various occasions. “For a clinical chemistry laboratory, ultrapure chemical standards and reagents are appropriately prepared, handled, and ultimately used in the hope of bringing the clinical research to a new level of precision and accuracy. These chemicals are referred to as clinical standards,” said one senior scientist from Alfa Chemistry. “As for now, clinical laboratories have a diversity of clinical reagents, antibodies, and molecular probes to choose from. Overall, these certified reference materials can facilitate serum analysis, histology, hematology, cytology, and a list of other sensitive and specific assays.” The creation and subsequent production of a reagent is no easy process, which usually takes a lot of factors into consideration. At Alfa Chemistry, two clinical standards are currently provided, namely the Iopromide (CAS: 73334-07-3) and Iopanoic acid (CAS: 96-83-3). Iopromide (CAS 73334-07-3), assay by HPLC with a purity of 98.0% and higher, is an iodinated contrast medium for intravascular administration and is commonly used in X-ray imaging studies to help in performing diagnostic tests of the brain, heart, head, blood vessels or other parts of the body. Iopanoic acid (CAS 96-83-3), assay by HPLC with a purity of 95.0% and higher, is an iodine-containing radiocontrast medium. This research-grade reagent is a substrate of type 1 deiodinase and can also be used in cholecystography. As always, Alfa Chemistry is at the forefront of technical innovation, strictly follows regulatory compliance, and strives to provide the best quality chromatography reagents and standards for customers worldwide. All reference standards are subjected to rigorous quality assurance checks prior to shipment. Visit https://reagents.alfa-chemistry.com/products/clinical-standards-634.html to learn more. About Alfa Chemistry During the past two decades, Alfa Chemistry has been dedicated to solving challenges and difficulties arising from the analytical testing industry. With the concerted efforts of the team, Alfa Chemistry now supplies a comprehensive range of reliable, high-purity reagents and standards for both manufacturers and analytical testing laboratories worldwide. Meanwhile, additional new product lines are regularly added to better serve the analytical science community.
'Physical and Chemical Characterization for APIs' image
Tech & Analysis
Physical and Chemical Characterization for APIs
Having a research team skilled at tackling highly complex and challenging characterization issues, CD Formulation recently demonstrated its ability to perform physical and chemical characterization services for active pharmaceutical ingredients (APIs) and pharmaceutical products in all stages of the drug development process.   The physicochemical properties of APIs, especially solubility, stability, in vitro dissolution and bioavailability, are of critical importance to pre-formulation as they will not only affect the choice and design of formulation, but also influence the performance of the dosage forms.   “A solid and thorough investigation into the physical and chemical properties of APIs is a primary step for quality control in the pharmaceutical industry,” said the Marketing Chief of CD Formulation. “With state-of-the-art instrumentation, our highly qualified technicians can undertake studies to specify the physicochemical characteristics of APIs as well as their intermediates.”   To test the physical characteristics of APIs, the following testing items should be carried out, including but not limited to XRPD Characterization, Particle Size Determination, Morphological Analysis, Surface Area Analysis, Thermogravimetric Analysis using equipment and methods like Polarizing Microscope (PLM) and Differential Scanning Calorimetry.   In contrast, to test the chemical characteristics of APIs, NMR is utilized to identify the chemical structure and quantify residual solvents. Fourier Transform Infrared and Near-infrared Absorption Spectra are used to scan fingerprints and recognize functional groups in molecular structure. Photoacoustic scanning is used to identify resin and opaque/colored materials. In addition, the Ultraviolet-Visible Absorption Spectrum is used to determine the characteristic absorption mode of raw materials or for qualitative detection, quantitative calculation and kinetic analysis.   “At CD Formulation, our experienced researchers work closely with our customers in designing and conducting pre-formulation studies and offer a wide range of approaches to characterize varieties of drug candidates such as small molecules, peptides or proteins,” a senior scientist further added.   Please visit our website to explore more of CD Formulation’s physical and chemical characterization capabilities.   About CD Formulation During the past few years, CD Formulation has served as a trust-worthy custom service provider for drug pre-formulation and has luckily made commendable achievements owing to its strong expertise and professionalism. Meanwhile, the company also has a track record of success in optimizing different dosage forms to bring the best therapeutic effects out of drug candidates, shortening development timelines as well as extending pharmaceutical product life cycles.
'Drug Delivery Research' image
R&D
Drug Delivery Research
As a reliable service provider in pharmaceutical formulation development, CD Formulation constantly expands its service range and today announces to offer a comprehensive portfolio of services for drug delivery system (DDS) research, including microneedle technology services, oral thin films technology services, microencapsulation technology services, liposome drug delivery technology services, cationic liposome technology services, lipid-based nanoparticles technology services for drug delivery systems, microparticle depots design and development services, microsphere technology development services, multiparticulate system formulation development services, and polymer nanoparticles for drug delivery services. The top priority for drug delivery research is to develop novel materials or carrier systems to achieve more effective therapeutic delivery of drugs. Conventionally, there are various drug delivery dosage forms, such as pills, capsules, tablets, solutions, suppositories, suspensions, injectables, etc. “Enhanced therapeutic effects are often accompanied by a more steady, controlled, and targeted drug delivery. With the advance of modern medicine, now a wide range of innovative drug delivery systems have been developed and applied, such as oral controlled release systems, fast dispersing dosage forms, taste-masking systems, and site-specific delivery systems,” said the Marketing Chief of CD Formulation. Currently, CD Formulation is capable of conducting the following drug delivery services for pharmaceutical companies: Microneedle Technology Services Microneedle process development technology can ensure effective delivery of drugs to the medicinal site. The length, size, and shape of the microneedles can be individualized according to the needs of the treatment. Oral Thin Films Technology Services Oral thin films avoid exposing the drug to the harsh conditions of the stomach and allows this drug delivery system to deliver a greater percentage of the active compound per dose. Hence, oral thin film technology enables rapid release of the active substance in the form of a single or multi-layer system. Microencapsulation Technology Services Microencapsulation technology improves and enhances the appearance of substances and their properties, stores microscopic substances, delays and controls release, and protects the core material from the environment. Liposome Drug Delivery Technology Services Liposome-encapsulated drugs can significantly reduce toxicity and side effects. CD Formulation’s liposome technology provides solutions to enable pharmaceutical companies to deliver a wide range of drug molecules. Cationic Liposome Technology Services Based on the development of liposome technology, CD Formulation has been developing cationic liposome technology to improve the drug loading capacity of liposomes, which can be used to effectively load negatively charged drugs, such as nucleic acid drugs. Lipid-Based Nanoparticles Technology Services for Drug Delivery Systems CD Formulation has extensive experience in conducting liposome drug delivery system technology services, liposome formulation development services, and modified liposome technology services. Microparticle Depots Design and Development Services CD Formulation can perform microparticle formulation development by adjusting polymer selection, particle size, and drug loading volume. Microsphere Technology Development Services Better drug delivery can be realized by developing microsphere technology and microsphere preparation processes. Multiparticulate System Formulation Development Services Multiparticulate system formulations are better distributed and less likely to cause local sensitization. Polymer Nanoparticles for Drug Delivery Services Polymer nanoparticles used in drug delivery can achieve slow or controlled release through diffusion or degradation of the polymer itself. Please visit our website to learn more. About CD Formulation Being innovative and science-driven, CD Formulation is at the forefront of contract research and always applies the latest science and technology to the pharmaceutical industry. All of its CRO services are carried out in concerted efforts to advance the global medical business.
'Peptides for Diabetes Research' image
R&D
Peptides for Diabetes Research
BOC Sciences has been constantly enriching its peptide product library for years. Its peptides for diabetes research are recently brought into focus due to the growing concerns on this problem. According to data from the WHO, a large number of adults are having diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia. The absolute lack of insulin, due to destruction of the insulin producing pancreatic β-cells, is the particular disorder in type 1 diabetes while type 2 diabetes is mainly characterized by the inability of cells to respond to insulin.  As one of the most challenging health problems of the 21st century, diabetes has been investigated for years with many promising drugs and therapies springing up. Some technologies about peptides have gained much attention since certain peptide drugs are proved to significantly promote insulin secretion and help restore the function of pancreatic beta cells. BOC Sciences, the world-leading biotech company, has also made its exclusive contribution by offering a series of peptides for diabetes research. BOC Sciences now adds quite a number of diabetes peptides to its collection, i.e., amylin (IAPP) & analogs, exendin & analogs, ghrelin & analogs, C-peptide, gastric inhibitory polypeptide (GIP), etc. The list is too long to be enumerated. The chief technician of BOC Sciences expatiates some information about C-peptide as an example, "Our C-peptide can alleviate and delay the occurrence and development of chronic complications such as kidney, nerve, and cardiovascular in patients with type 1 diabetes by activating some enzymes, which provides a new solution to the treatment of type 1 diabetes." Some peptides in the BOC Sciences inventory are also valued as critical tools in the R&D of drugs for type 2 diabetes. For instance, islet amyloid polypeptide (IAPP), a major component of the pancreatic amyloid deposits found in the pancreas of patients with type 2 diabetes, may be involved in the pathogenesis of type 2 diabetes. IAPP is now evidenced to lower blood sugar by reducing postprandial glucagon secretion, delaying gastric emptying, and suppressing appetite. BOC Sciences generally prepares IAPP by genetic engineering and then supplies them to customers specializing in the clinical treatment of type 2 diabetes. More broadly, some IAPP analogs, i.e., pramlintide also show positive effects as adjunctive drugs for type 1 diabetes. Accompanied by the rising attention to diabetes therapeutics, BOC Sciences also invests equal or even more energy in developing peptides & analogs for diabetes. More information can be accessed at our website. About With years of experience in peptide manufacturing and synthesis, BOC Sciences has made commendable achievements in custom peptide synthesis and production. Presently, its peptide products can be applied in the treatment of multiple diseases (diabetes, cancer, Alzheimer's disease, HIV, HPV, etc.) and have very good curative effects.
'NTPs during the Pandemic' image
Tech & Analysis
NTPs during the Pandemic
"Whether your studies involve DNA sequencing, cDNA synthesis, RT-PCR, RCA, MDA, DNA labeling, in vitro transcription, siRNA synthesis, or RNA amplification, we stock hundreds of modified or natural NTPs to suit your various molecular biological applications," a BOC Sciences manager announces to the public. As an active participant in the biotech and pharmaceutical industry, BOC Sciences emphasizes its enterprise in nucleoside triphosphates & nucleotides development in recent years since there are pressing demands on raw materials for mRNA technology development. There is a special list of mRNA vaccine related raw materials at BOC Sciences, suggesting its enormous contribution to the anti-COVID-19 campaign. The comprehensive inventory encompasses ribo-Nucleoside diphosphates (NDPs), ribo-Nucleoside monophosphates (NMPs), ribo-Nucleoside triphosphates (NTPs), Cap Analogs, and more. With these industry-leading offerings, many mRNA vaccine developers breathe a sigh of relief since they are now able to obtain certified and sustainable raw materials for their mRNA vaccine projects. BOC Sciences takes quality control of NTPs very seriously, which accounts for a large number of its new customers coming back for subsequent cooperation while regular customers would like to unswervingly maintain the partnership. All the ribo-Nucleoside triphosphates (NTPs) are extensively tested and validated for downstream applications. They boast a high level of purity and are verified by HPLC. Quality testings help ensure that NTPs have excellent performance in molecular biology experiments. In addition to HPLC, BOC Sciences has employed a variety of analytical methods for quality assessment. It's worth noting that BOC Sciences supplies NTP sets of ATP, CTP, GTP, and UTP for distinct scientific or commercial purposes. Its complete NTP inventory shows the advantage of reduced outsourcing workload for customers who are running multiple projects simultaneously. Additionally, BOC Sciences' nucleic acid chemists are experts in the synthesis of unique NTPs. With demands for larger quantities, specific concentrations, or custom nucleotide synthesis, researchers or corporate purchasers can get tailored support upon request. Summed up in one sentence, BOC Sciences does what customers want and considers about what they care, which drives it to the top position in the industry. "We have cultivated multiple methods to manufacture NTPs such as chemical synthesis or other alternative tactics such as enzymatic synthesis. With the constant advances in techniques, there's a reasonable prospect that our NTPs will bring better economic effectiveness and more quality assurance to a broad scope of partners," said the BOC Sciences technical adviser. About BOC Sciences provides a wide range of chemicals and biochemicals. Its quality NTPs have served global researchers or corporations in the research about DNA sequencing and other molecular biology applications.

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'Nine Most Commonly Seen Additives in Plastics' image
Tech & Analysis
Branded
Nine Most Commonly Seen Additives in Plastics
Reinforcing materials and fillers In many plastics, reinforcing materials and fillers occupy a considerable proportion. In order to improve the strength and rigidity of plastic products or reduce production costs, various fiber materials or inorganic substances are added. The most commonly used reinforcement materials are: glass fiber, asbestos, quartz, carbon black, silicate, calcium carbonate, metal oxides, etc. Coupling agent Coupling agent refers to a class of substances that can improve the interface properties between fillers and polymer materials. Usually there are two functional groups in the molecular structure of the coupling agent: one can chemically react with the polymer matrix or have good compatibility; the other can form chemical bonds with the inorganic filler. For example, silane coupling agent, the general formula of which can be written as RSiX3, where R is an active functional group that has affinity and reactivity with polymer molecules, such as vinyl, chloropropyl, epoxy, methacryloyl, amine and mercapto, and X is an alkoxy group that can be hydrolyzed, such as methoxy, ethoxy, etc. At present, organosilane is the most widely used coupling agent, and organotitanate is a more efficient coupling agent. Cross-linking agent Crosslinking agents are mainly used in polymer materials (rubber and thermosetting resins). Because the molecular structure of the polymer material is a linear structure, the strength is low when it is not cross-linked and it’s easy to break. A network structure is formed, which improves the strength and elasticity of the rubber. The crosslinking agent used in the rubber is mainly sulfur, and an accelerator is added. The general cross-linking agent mostly refers to organic peroxide. For instance, dicumyl peroxide can be used as the cross-linking agent for polyethylene. Foaming agent Foaming agent is a kind of substance that can make rubber and plastic in a liquid or plastic state to form a microporous structure. According to the mechanism of action, foaming agents can be divided into physical foaming agents and chemical foaming agents. Physical foaming agent is a type of compound that relies on the change of its physical state during the foaming process to achieve the purpose of foaming; while chemical foaming agent will thermally decompose at a certain temperature to generate one or more gases to foam the polymer. Nucleating agent (https://polymer-stabilizer.alfa-chemistry.com/products/nucleating-agent-2342.html) Nucleating agent is suitable for incomplete crystalline plastics such as polyethylene and polypropylene. By changing the crystallization behavior of the resin, it can speed up the crystallization rate, increase the crystallization density and promote the miniaturization of the grain size, so as to shorten the molding cycle, improve the transparency and surface of the product. Colorant Colorants are insoluble in common solvent chemicals. To obtain ideal coloring properties, the pigments need to be uniformly dispersed in the plastic by mechanical methods. Inorganic pigments have excellent thermal stability and light stability, low price, but relatively poor tinting strength and high relative density. In contrast, organic pigments have high tinting strength, bright color, complete color spectrum, and low relative density. Colorants mainly include masterbatches and optical brighteners. Masterbatch is a kind of aggregate prepared by uniformly loading super-constant pigments or dyes in resin. Its basic composition includes: pigments or dyes, carriers, dispersants, additives. Fluorescent whitening agent is a fluorescent dye, and can be classified into several sub-categories, including carbocyclics, triazinylaminostilbene, stilbene-triazoles, benzoxazoles, furans, benzofurans and benzimidazoles, 1,3-diphenyl Base-pyrazoline, coumarin, naphthalimide and others. Antibacterial agents With the continuous enhancement of people's safety awareness, more and more people begin to buy antibacterial plastic products. Antibacterial agents are used in antibacterial plastics. Antibacterial agents refer to chemical substances that can keep the growth or reproduction of certain microorganisms, such as bacteria, fungi, yeast, algae and viruses, etc., below a necessary level for a certain period of time. Antibacterial agents are substances with bacteriostatic and bactericidal properties. Flame retardant The additives that slow down the combustion performance of plastics are called flame retardants. Most of the plastics containing flame retardants are self-extinguishing or have the effect of slowing down the burning rate. Antistatic agent Any object has its own electrostatic charge, which can be negative or positive. The accumulation of electrostatic charges affects or even harms life or industrial production. Chemical substances that guide/eliminate the accumulated harmful charges so that they do not cause inconvenience or harm to production or life are called antistatic agents. Antistatic agents generally have the characteristics of surfactants, and have both polar groups and non-polar groups in structure. The commonly used polar groups are: anions of carboxylic acid, sulfonic acid, sulfuric acid, phosphoric acid, cations of amine salts, quaternary ammonium salts, and -OH, -O- and other groups. The commonly used non-polar groups, namely, lipophilic groups or hydrophobic groups, include alkyl groups, alkaryl groups, and the like. Antistatic agents can be of five basic types: derivatives of amines, quaternary ammonium salts, sulfates, phosphates, and derivatives of polyethylene glycols. Alfa Chemistry is chemical supplier that provides a comprehensive range of stabilizers, including antioxidant, flame retardant, heat stabilizer, light stabilizer, mould inhibitor, optical brightener, plasticizer, and synthetic auxiliary. All can be used as additives for plastics.

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