Everything about the lab industry

CD ComputaBio, a reliable computational biology service provider located in New York, is always hammering at research and trials in order to provide customers with access to the latest software, technologies, and expertise at a competitive price and fast turnaround time. The company has recently launched 3D-QSAR services for scientists to accelerate the drug development process. Quantitative structure-activity relationship (QSAR) is a method, by means of mathematical and statistical methods with the help of the physical and chemical properties of molecules or structural parameters, for quantitatively studying the interaction between small organic molecules and biological macromolecules, meanwhile revealing the physiologically related properties of small organic molecules such as absorption, distribution, metabolism, and excretion in organisms. 3D-QSAR introduces the three-dimensional structure information of the drug molecule, which indirectly reflects the non-bonded interaction characteristics between the drug molecule and the macromolecule. Currently, the most widely used 3D-QSAR methods are the comparative molecular field method (CoMFA) and the comparative molecular similarity method (CoMSIA). In recent years, 3D-QSAR methods based on receptors have also been developed. This method introduces receptor structure information, which provides more information than traditional ligand-based 3D-QSAR methods (CoMFA and CoMSIA), and directly reflects the interaction mode between drug molecules and biological macromolecules. “Through our 3D-QSAR research service, researchers can indirectly obtain the interaction mode between drug molecules and biological macromolecules, so as to make targeted structural modifications or screen out novel emerging compounds. Therefore, it improves the efficacy (activity) or selectivity and the pharmacodynamic properties, reduces the toxicity/carcinogenic and teratogenic potential, and circumvents intellectual property issues. ” Commented Senior Scientist of CD ComputaBio. The overall solutions provided by CD ComputaBio include: 1. Data mining approach Molecule mining techniques are a subset of structured data mining techniques. It predicts molecular substructures using a similarity matrix or an automatic fragmentation scheme. Other methods, such as maximum common subgraph searches or graph kernels, are also available. 2. Matched molecular pair analysis Typical QSAR models derived from nonlinear machine learning are regarded as a "black box" that fails to provide useful information to medicinal chemists. The concept of matched molecular pair analysis, or prediction driven MMPA, is a relatively new concept that is used in conjunction with a QSAR model to identify activity cliffs. CD ComputaBio has rich practical experience and core technology in quantitative structure-activity relationship research. In addition to 3D-QSAR service, it also provides the following services to facilitate your drug development process: 1. Structure-based Virtual Screening (SBVS) Service 2. Reverse Virtual Screening 3. 2D-QSAR Service About CD ComputaBio With years of experience, CD ComputaBio can provide customers with professional computational biology services. Utilizing rich experience and powerful technology in computational science, the company can provide customers with many computational biology analysis services such as molecular dynamics simulation, drug design, virtual screening, quantum chemical calculations, etc. You can learn more information about 3D-QSAR at https://www.computabio.com/3d-qsar-service.html

Tosoh Bioscience LLC, a leading supplier of separation and purification products and technologies to the life sciences industry, announced today that it has completed the acquisition of Semba Biosciences, a privately held Wisconsin company. Semba Biosciences is a leading innovator in the field of multi-column chromatography (MCC) instrumentation and technology for downstream purification of biologics. Ali Soleymannezhad, VP of global marketing and business development of Tosoh Bioscience LLC said, “We are thrilled to welcome the Semba Biosciences team to the Tosoh family. For long we have admired Semba’s technology and innovation, pioneering the Simulated Moving Bed (SMB) technology in the bio purification processes. Since our first equity investment back in 2018, the company has successfully hit every product development milestone set by Tosoh Bioscience and will soon be ready to launch the Octave BIO System, a state-of-the-art benchtop MCC unit for bioprocess development, and ProGMP, the most efficient MCC skid designed for larger-scale biological manufacturing. This marks a new era for Tosoh Bioscience and confirms our commitment to provide our customers with the latest solutions and technologies.” “We are extremely pleased and excited to become part of the Tosoh Bioscience worldwide organization,” said Robert Mierendorf, Ph.D., president, and CEO of Semba Biosciences. “By combining Semba Biosciences’ advanced Simulated Moving Bed (SMB) technology with Tosoh Bioscience’s best-in-class resins, we will be able to offer unparalleled efficiency and productivity in downstream processes and significantly decrease the cost of manufacturing.” Tosoh Bioscience LLC is planning on expanding the current Semba team in Madison, WI, creating a global center of excellence for continuous chromatography. TOSOH BIOSCIENCE LLC/GmbH Tosoh Bioscience LLC/GmbH provides liquid chromatography products to laboratories and manufacturing plants in the Americas. While the majority of our customers work in biotechnology and pharmaceutical companies, our U/HPLC columns and systems are essential tools for sample analysis in most industries. The LenS3 Multi-Angle Light Scattering Detector offers a revolutionary approach for the measurement of molecular weight (MW) and radius of gyration (Rg) of synthetic polymers, polysaccharides, proteins, and biopolymers. Our all-in-one dedicated GPC system, the EcoSEC GPC System, is predominantly used in the chemical and polymer industries while our EcoSEC High-Temperature GPC System is ideal for the polyolefin and oil industries. In the field of biotechnology, our preparative chromatography resins play a critical role in the purification of proteins and nucleic acids for medical purposes. The company is a subsidiary of Tosoh Corporation in Japan, the parent of the Tosoh Group, which comprises over 100 companies worldwide and a multiethnic workforce of over 12,000 people and generated net sales of ¥732.9 billion (US $6.9 billion at the average rate of ¥106.1 to the US dollar) in fiscal 2021, ended March 31, 2021. Tosoh’s Bioscience Division comprises products and solutions of both separation and purification and of clinical diagnostics serving customers worldwide.

Science Park University of Antwerp is a stimulating business park for innovative entrepreneurs in the field of ‘Life sciences and Environmental sciences’. Within a dedicated network, entrepreneurs are supported and their chances of success improved, enabling them to successfully start up, grow and keep innovating. This dynamic network facilitates cross-pollination between entrepreneurs, experts, knowledge institutes and governments. Science Park University of Antwerp has a complementary and high-quality offer of business infrastructures in lease, rent and purchase formulas, as well as grounds. Incubator Darwin is the heart of the park. With its open architecture, attractive meeting rooms and trendy coffee bar, incubator Darwin is the place to be for young entrepreneurial talent. Impress clients and investors in this beautiful building with panoramic views of the waterfront behind. Available at the moment is a lab space of 52 m² on the first floor of the building. Contact us for more information.

Do you need to expand your laboratory equipment, but you do not have the options to purchase? Or do you temporarily need an expansion of capacity? At LabMakelaar Benelux B.V. you can also rent laboratory equipment for a short or longer period. Whether it concerns equipment, furniture or glassware, with us you can temporarily expand your laboratory in an economical way. Do you want to know what we can do for you? Please contact us.

A biological sample testing laboratory needed to check blood samples for COVID-19 anti-bodies during the 2020 - 2021 pandemic. To make this happen, huge quantities of blood samples had to be serologically tested and stored in tubes in freezers and then for up to 10 years in liquid nitrogen as a backup. With huge and growing numbers of infected people, the process had to be fast and efficient. One of the challenges the laboratory needed to address quickly, was sample labeling. Their current label printer was failing them and absorbed too much time because it had to be calibrated manually. Solution: Auto-calibration and software integration Together with a specialized distributor, Brady proposed the BradyPrinter i3300 Industrial Label Printer together with B-492 labels. The printer recognizes the label material on insertion, immediately auto-calibrates, and is ready to deliver perfect prints, all within 20 seconds. This significantly reduced time spent by scientists on label printing, time much better spent on testing blood samples in the fight against the pandemic. Additionally, respecting anti-viral social distancing measures, a call was set up to integrate the printer with the customer’s existing software systems. This resulted in automated label printing, within an existing process scientists were already familiar with. On top of this, the B-492 ‘FreezerBondz’ label that could now be printed almost automatically, isn’t just any label. It perfectly fits tubes, it can resist common laboratory chemicals and the label stays legible and attached in liquid nitrogen storage temperatures at -196°C when printed with the BradyPrinter i3300. Results: Fast, first-time-right label printing Scientists in the biological sample testing laboratory can now quickly print and apply a reliable label on a tube blood sample. With printer auto-calibration, they no longer need to spend time on printer settings and re-printing labels.