Waters introduced at the end of January, a new biopharma column chemistry called BioResolve RP mAb Polyphenyl. This column is to be used for reversed-phase analysis of intact mAbs, their subunits or antibody-drug conjugates (ADCs).
It is developed using a reduced IdeS-digested NIST mAb reference material that Waters uses to quality-test each batch of stationary phase and is also shipped with the columns as a reference standard (and is also available separately).
It consists of a 2.7 µm solid-core particle with a 450Å pore size polyphenol bonded phase for superior peak shape and resolution in MS-friendly mobile phases.
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