Creative Biostructure Unveils Cryo-EM Single-particle Analysis Service

29 March 2022
Article image of: Creative Biostructure Unveils Cryo-EM Single-particle Analysis Service

Creative Biostructure, a biotechnology company specialized in providing cost-effective contract services to both academia and biotech industries in the field of structural biology, provides a comprehensive list of cryo-em related technologies including Cryo-EM Single-Particle Analysis.

Cryo-EM is an ultra-low temperature cryo-sample preparation and transfer technology (Cryo-EM) based on electron microscope, which can directly observe liquids, semi-liquids and samples sensitive to electron beam, such as biological samples and polymer materials. In 2017, cryo-EM technology won the Nobel Prize in Chemistry, and is currently the most advanced technology in the field of biomedicine, with the potential and the broadest prospects for preclinical drug development and application.

Single Particle Analysis (SPA) is a set of related computer image processing techniques used to analyze images acquired on Transmission Electron Microscope (TEM). These methods were developed to improve and extend the ability to obtain structural biological information from TEM images of particle samples, typically proteins or other large biological entities such as viruses. In recent years, single particle analysis technology has become one of the many structural elucidation methods in structural biology.

Creative Biostructure provides comprehensive and unbundled cryo-EM SPA services, including but not limited to molecular cloning, protein expression, protein purification, cryo-EM SPA sample preparation, electron microscopy imaging, data processing, and interpretation. In addition, according to the official speaker from Creative Biostructure, if customers choose the cryo-EM SPA service, the company can provide with negative-stained EM at no cost to screen out high-quality cryo-EM samples.

“If your research project involves difficult to crystallize biological macromolecules or protein complexes, then our cryo-EM SPA service will effectively provide you with structural details about these molecules.” Adds Joanna, the chief marketing staff at Creative Biostructure Marketing Department.

Moreover, the company provides electron crystallography service, cryo-electron tomography, microcrystal electron diffraction, and negative staining TEM to assist scientists with their research.

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