An automated laboratory where data, methods and processes are seamlessly shared between software applications and analytical instruments. The ultimate goal for a digitalized laboratory is to leverage the power of the data and provide useful information, business intelligence for decision makers sitting at any step of the data life cycle. Fact is that rarely the laboratory reaches the point to feel completely automated and free of paper processes. For a reason or another, instruments integration remains the last item in the project for ever, final users have difficulties to interact with the tool as expected, excels files are still the key asset for decision making, etc. If the initial decisions were focused on implementing solutions to gain efficiency and shorten time to market, it is recommended to approach such digital transformation projects with clear understanding of some key points, avoiding frustrations and low return on investment.