Alfa Chemistry announces that it releases a portfolio of protection reagents for researchers worldwide, which will help solve one of the biggest difficulties in the multi-step synthesis of natural products.
In organic synthesis, several sites or functional groups in a molecule may react with the reactants, but only specific sites are needed for the reaction process. Thus, chemoselectivity in functional group transformations is always a critical issue that needs to be tackled.
“Efficient protection should meet several criteria. First, they should selectively and easily react with protected groups to achieve high conversion rates. Second, they should be stable throughout the whole synthesis process. Moreover, the protecting group in the protection reagents should be easily removed when not needed or when the functional group requires manipulation,” says the Marketing Chief of Alfa Chemistry.
The following protection reagents are provided by Alfa Chemistry:
2-(Trimethylsilyl)ethoxycarbonylation (Teoc) Reagents
9-Fluorenylmethyloxycarbonylation (Fmoc) Reagents
Acetalization Reagents
Acylation Reagents
Alkoxymethylation Reagents
Allylation Reagents
Allyloxycarbonylation (Alloc) Reagents
Benzylation (Bn) Reagents
Benzyloxycarbonylation (Cbz) Reagents
Photolabile Protection Reagents
Silylation Reagents
Sulfonylation Reagents
tert-Butoxycarbonylation (Boc) Reagents
Thioacetalization Reagents
Trichloroethoxycarbonylation Reagents
Tritylation (Tr) Reagents
Other Protecting Reagents
Protection reagents have multiple applications in organic synthesis, and special focus goes to the following areas:
Carbohydrate chemistry
Protection reagents play a key role in the synthesis of complex natural products such as oligosaccharides. The DMP-group was used in the synthesis of several β-glucosamines, which has shown to be stable to certain basic and acidic reaction conditions and could be readily removed using NaOH or hydrazine.
Peptide chemistry
Protection reagents are also needed in the synthesis of peptides. Proper protection reagents manipulation strategies can maximize the yield of the desired product or allow the construction of complex peptide-based structures.
Oligonucleotide synthesis
In the chemical synthesis of natural products having phosphoric acid esters, the phosphate protection reagents should be selected.
