Organic chemistry lays a solid foundation for drug discovery, chemical biology, materials science, engineering and many other fields. Always keeping an eye on the research focus, Alfa Chemistry Catalysts recently announces to offer chiral N-heterocyclic carbenes, one type of asymmetric organocatalysts, for wide use in organic synthesis.
N-heterocyclic carbene (NHC) ligands behave well in many catalytic processes, and thus have attracted much attention together with their related metal complexes ever since their early development. With continuous research carried out on them, NHC have further proved their value as a versatile class of spectator ligands in homogeneous catalysis. Structural variations on the heterocycle make it easy to fine tune their steric and electronic properties.
“As one of the most widely studied nucleophilic carbene, chiral N-heterocyclic carbenes have many advantages as well as stronger electrons. Firstly, they are more stable in air. Secondly, they can form complexes with both metallic and non-metallic elements. Last but not least, their strong nucleophilicity will make the complex formation more stable under severe conditions,” says a spokesperson from Alfa Chemistry Catalysts.
With expert knowledge and many years of study and hands-on laboratory practice, the scientific team of Alfa Chemistry Catalysts are fully aware of what researchers truly need in their organic synthesis projects. Now the company provides a wide range of chiral N-heterocyclic carbenes for customers worldwide. Below are just some of them:
(R)-Benzyl-2-[4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazolium Tetrafluoroborate (CAS 862095-77-0), (+)-(5aR,10bS)-5a,10b-Dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazinium Chloride Monohydrate (CAS 903571-02-8), (-)-(5aS,10bR)-5a,10b-Dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazinium Chloride Monohydrate (CAS 919102-70-8), (S)-Benzyl-2-[4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazolium Tetrafluoroborate and more.
For more information about Alfa Chemistry Catalysts’ offering of chiral N-heterocyclic carbenes, please visit https://www.alfachemic.com/catalysts/products/chiral-n-heterocyclic-carbenes-nhc.html or email us directly.
Application of Chiral N-Heterocyclic Carbenes
The use of NHCs in organic synthesis has led to substantial advances in transition-metal catalysis and organocatalysis over the past decade. Chiral NHCs can not only serve as a substrate for organic reactions. Moreover, extensive research has shown that they can be used as a class of privileged chiral ligands to form complexes with metal or non-metal elements to catalyze many types of reactions, including coupling reaction, dilute hydrocarbon metathesis reaction, asymmetric catalytic reaction as well as many other reactions such as hydrogenation, polymerization, ring opening, transesterification and the like.
Starting to supply varieties of catalysts years ago, Alfa Chemistry Catalysts has been recognized as a trust-worthy supplier in the pharmaceutical and biotechnology industries, offering chiral catalysts, ligands, metal catalysts, non-metal catalysts, organocatalysts, phase transfer catalysts, photocatalysts and many other catalysts for various reactions and scenarios.
