Cytokine division belongs to Creative Proteomics, which specializes in providing cytokine research and analysis services for researchers in the pharmaceutical and biotechnology industries, as well as academic institutes and government agencies. Creative Proteomics is proud to announce the launch of the high-sensitivity inflammatory cytokine assays. These assays offer ultra-sensitivity, excellent specificity with no cross-reaction to other cytokines, and the ability to test multiple sample types.
Cytokines are protein molecules that help regulate the body’s immune response to infection and trauma. Some promote wound healing, while others, such as pro-inflammatory cytokines increase inflammation and may contribute to disease progression. Interleukins and tumor necrosis factor are inflammation-promoting substances in the immune system that often lead to fever and inflammation throughout the body. Some researchers believe that the constant interaction and balance between inflammatory and anti-inflammatory cytokines is an essential part of the human immune system.
Pro-inflammatory cytokines are secreted by Th1 cells, CD4+ cells, macrophages, and dendritic cells. Pro-inflammatory cytokines are characterized by the production of various interleukins (IL), such as IL-1, IL-2, IL-12, IL-17, IL-18, IFN-γ and TNF-α. The key pro-inflammatory cytokines are IL-1, IL-6 and TNF-α. These cytokines signal through the type I cytokine receptor (CCR1), which is structurally distinct from other types of cytokine receptors. They are essential for coordinating cell-mediated immune responses and play an important role in regulating the immune system. Pro-inflammatory cytokines typically regulate the growth, activation, differentiation, and homing of immune cells to the site of infection, aiming to control and eradicate intracellular pathogens, including viruses.
Inflammatory cytokines can regulate the response of pro-inflammatory cytokines, including IL-4, IL-5, IL-10, IL-13, transforming growth factor (TGF), epidermal growth factor, etc. Among them, IL-4 can inhibit the production of other pro-inflammatory cytokines such as IL-1 and IL-6, as well as the production of lymphocytes and macrophages. IL-10 can inhibit the production of activated monocytes, macrophages, granulocytes and T cells. IL-13 can inhibit the production of pro-inflammatory mediators, down-regulate the function of monocytes, and has cytotoxicity. TGF-β can suppress the inflammatory response in the gut. EGF can stimulate tissue repair and protect the gastrointestinal mucosa.
“Cytokines do not operate independently, but in an activation and inhibition network. Assessing inflammatory responses by measuring individual cytokines often does not reflect the complexity of inflammation. To overcome this problem, the use of multiplexed or multifactorial assays is very effective because it captures many different secreted cytokines, which allows analysis of hundreds of targets simultaneously,” stated Creative Proteomics’s senior scientist.
“Creative Proteomics mainly uses the Luminex cytokine detection platform for cytokine detection. Our dedicated analysts will customize exclusive solutions for you according to different purposes. Our Luminex cytokine detection platform uses fluorescently encoded microspheres with specific antibodies to different target molecules. The different microspheres can be combined freely to a certain extent, so that up to 100 analytes can be tested multiple times simultaneously in a single experiment,” he added.
About Creative Proteomics
Creative Proteomics is an innovative contract research organization that focuses on using advanced equipment platforms and optimized detection technology to help researchers around the world reduce time and costs. The company has a proprietary laboratory information management system to strengthen laboratory quality monitoring and quality management to ensure the efficiency and security of customer data.
Contact
Address: Shirley, NY 11967, USA
Email: [email protected]
Website: https://cytokine.creative-proteomics.com/cytokines-in-inflammation.htm
