BOC Sciences, known as a trust-worthy supplier of inhibitors, metabolites, impurities, ADCs, pharmaceutical excipients, APIs and intermediates, recently announces the release of nucleosides for various research use. The nucleosides provided can be classified into three categories: fluorescent nucleosides, antimetabolic nucleosides, as well as cancer and proliferation marker nucleosides. Some are in stock and ready for use while others can be synthesized according to customer`s specific needs. Composed of a nucleic acid base and a sugar, nucleosides are the basic building blocks of nucleic acids (DNA and RNA), which play a significant role in genetic information expression. As to the difference form nucleosides, nucleotides can be interpreted as phosphorylated nucleosides. Nucleosides are commonly obtained in vitro through de novo synthesis pathways and decomposition of nucleic acid which is from diet. In addition, nucleotides are of particular importance for the replication of DNA and transcription of RNA in rapidly dividing stages. Besides, they participate in cell metabolism as well. BOC Sciences has directed sincere efforts toward providing customers with the following three high quality nucleosides with optimal prices. Fluorescent Nucleosides With the broad use of fluorescent molecules in the biochemical and pharmaceutical industry, fluorescent nucleosides are also in great demand. Labeled with some special groups that can emit fluorescence, fluorescent nucleosides are widely used in nucleic acid sequence determination, detection of pathogenic pathogens, diagnosis of genetic disease, gene expression analysis, etc. There are natural fluorescent nucleosides and artificially synthesized fluorescent nucleosides. Nowadays, many novel use of fluorescent nucleosides are being explored. Antimetabolic Nucleosides Owing to their antiviral and antitumor activities, antimetabolic nucleosides offers new insights on disease treatment, such as cancer. Meanwhile, they also can be used to prevent the replication of viruses in infected cells, such as hepatitis B virus, hepatitis C virus, HIV, herpesvirus, and Ebola virus. Some of the most widely researched antimetabolic nucleosides are: 1-β-D-arabinofuranosyl-cytosine (araC), 2-chloro-2`-deoxyadenosine (CldA), Cytarabine. Cancer and Proliferation Marker Nucleosides Another major therapeutic use of nucleosides is that they can be used to detect newly synthesized DNA and RNA or as measurement for cancer markers, considering their role in maintaining the hyperproliferative state of cancer cells. N1-Methyl-adenosine, 5-Methyl-uridine, N3-Methyl-uridine and Pseudouridine are all marker nucleosides, whose elevated level in cells are associated with cancer. For more information about the nucleosides provided at BOC Sciences, please visit our website. Meanwhile, varieties of nucleotides are also available.

Written by